Dual versus Single Hypothermic Oxygenated  Machine Perfusion: A Multicentre Study

SG Leaders: Krishna Menon

                      Abdul Rahman Hakeem

Summary:

Background/rationale

Hypothermic oxygenated machine perfusion (HOPE) reduces ischaemia-reperfusion injury (IRI) in donor livers and is increasingly used in clinical transplantation 1,2. Centres use either dual perfusion (via both hepatic artery and portal vein; D-HOPE) or single perfusion (via portal vein alone; HOPE), depending on the centre’s expertise, preference, and available resources 3. However, it remains unclear whether perfusion via the D-HOPE or HOPE has any difference in outcomes both in short- and mid-term.

Objectives

1. To compare the outcomes of D-HOPE and HOPE with respect to reperfusion syndrome, early allograft dysfunction, primary non-function, acute kidney injury, post-operative vascular and biliary complications, graft survival, and patient survival. 
2. To compare perfusion machine related issues comparing D-HOPE and HOPE